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Progression to end-stage kidney disease ESKD is due to interstitial fibrosis, tubular atrophy, collapsing glomeruli, and mesangial proliferation [9]

In addition, a relative insulin deficiency stimulates gluconeogenesis in the liver and lipolysis in the adipose tissue, resulting in the release of glucose and free fatty acids, and, thereby further increasing the levels of circulating energy sources

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Encapsulation efficiency of CPT in the nanocarriers was recorded to be 87%